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The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia.
Cancer Res. 2024 Apr 1;84(7):1084-1100. doi: 10.1158/0008-5472.CAN-23-2659.
Cancer Res. 2024.
PMID: 38266099
Co-targeting of HDAC, PI3K, and Bcl-2 results in metabolic and transcriptional reprogramming and decreased mitochondrial function in acute myeloid leukemia.
Hege Hurrish K, Qiao X, Li X, Su Y, Carter J, Ma J, Kalpage HA, Hüttemann M, Edwards H, Wang G, Kim S, Dombkowski A, Bao X, Li J, Taub JW, Ge Y.
Hege Hurrish K, et al.
Biochem Pharmacol. 2022 Nov;205:115283. doi: 10.1016/j.bcp.2022.115283. Epub 2022 Oct 5.
Biochem Pharmacol. 2022.
PMID: 36208684
Free PMC article.
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